• Compared to previously reported atypical N

  2022-01-29

  

  Compared to previously reported atypical N-glycosites that were identified based on the deamidation of asparagine residues after PNGase F treatment [106], [107], these two studies further validated the identified atypical motif glycosites by directly identifying their intact glycopeptides. Since the

• In prostate cancer PCa glucose metabolism plays a

  2022-01-29

  

  In prostate cancer (PCa), glucose metabolism plays a major role in progression [14]. Androgens can activate the metabolic regulator AMP-activated kinase (AMPK), promoting oxidative phosphorylation (OXPHOS) [15]. Besides, androgens increase GLUT1 [16], which overproduction has been described in the m

• Acarbose and voglibose the classic glucosidase inhibitors we

  2022-01-29

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• Nevertheless in the brain we found that trehalose phosphoryl

  2022-01-29

  

  Nevertheless, in the brain, we found that trehalose phosphorylates AMPK, which is a metabolic sensor. AMPK is known to be transiently activated in muscle by acute exercise [21,22]. Bayod et al. also reported that AMPK was significantly activated in both the cerebral cortex and hippocampus in exercis

• Cortisol targets many organs and tissues and

  2022-01-29

  

  Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood Ac-DEVD-AFC receptor barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own produ

• br Acknowledgements br Introduction Glucagon a amino

  2022-01-29

  

  Acknowledgements Introduction Glucagon, a 29-amino Mdivi 1 receptor peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1]. The regulation of gluc

• br Discussion br Author Contributions br Alzheimer s

  2022-01-29

  

  Discussion Author Contributions Alzheimer’s disease (AD) is an age-related, chronically progressive neurodegenerative disorder affecting more than 35million people worldwide and an estimated 5.5million in the US. Current marketed drugs such as acetylcholinesterase inhibitors and the NMDA ant

• br Materials and method http

  2022-01-29

  

  Materials and methods Results Discussion This study provide for the first time a report on GALP in fish, providing new information towards the distribution and functional characterization of the galaninergic system in these vertebrates. Our studies show the detailed neuroanatomical distribu

• (+)-Catechin hydrate Determination of enzyme activity differ

  2022-01-29

  

  Determination of enzyme activity differs from other analytical procedures. In this (+)-Catechin hydrate case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for enzym

• More recently Serna Marquez and colleagues investigated LA i

  2022-01-28

  

  More recently, Serna-Marquez and colleagues investigated LA-induced migration and invasion of MDA-MB-231 breast cancer cells. In this study, LA was shown to induce AKT-2 phosphorylation and cell invasion and migration in MDA cells. LA-induced cell migration was inhibited by siRNA that selectively ta

• br Acknowledgments This study was supported by a Conquer

  2022-01-28

  

  Acknowledgments This study was supported by a Conquer Cancer Foundation (American Society for Clinical Oncology) Drug Development Research Professorship Grant (AAA). Introduction Gastric cancer (GC) is one of difficult cancers to treat in terms of its poor prognosis and limited applicability

• br Acknowledgments We thank Prof Alexander D Johnson

  2022-01-28

  

  Acknowledgments We thank Prof. Alexander D. Johnson and Suzanne M. Noble for kindly providing SN strains. This work was supported by Chinese National Natural Science Foundation Grants 31370105 and 31300057, and Shanghai STCSM Grant 12JC1409300. Introduction Organisms modulate gene expression

• Histamine receptors were largely linked with allergic and in

  2022-01-28

  

  Histamine receptors were largely linked with allergic and inflammatory reactions before the recognition of the histamine H3R in 1983 that proved its function as auto- as well as heteroreceptor at pre- and postsynaptic membranes and demonstrated its intense regulating influence on release of numerous

• Although we showed that RBL

  2022-01-28

  

  Although we showed that RBL-2H3 Sc98 Losmapimod took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including SER

• Several studies have also shown that HK may be

  2022-01-28

  

  Several studies have also shown that HK2 may be an important downstream quercetine australia of the PI3K/AKT/mTOR signaling pathway and may contribute to the development of cancer [15]. In our previous study, we found AKT2 expression was positively correlated with HK2 expression in primary colon ca

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